Journal: Clinics

Article Title: Comparative efficacy of melatonin and glutathione in mitigating carboplatin-induced ovarian toxicity in rats

doi: 10.1016/j.clinsp.2026.100902

Figure Lengend Snippet: Representative photomicrographs of immunohistochemical staining for Cas-3, NF-κB, and AMH in ovarian sections from control, GSH, Mel, CARB, GSH+CARB, and Mel+CARB groups. (Olympus BX51, Tokyo, Japan. Scale bar; 200 µm). Strong Cas-3 and NF-κB staining in the CARB group indicated increased apoptosis and inflammation, while AMH expression was markedly reduced, reflecting diminished follicular reserve. Pre-treatment with melatonin or glutathione attenuated apoptotic and inflammatory responses and restored AMH immunoreactivity to near-control levels.

Article Snippet: Primary antibodies cleaved Cas-3 (Cell Signaling Technology, Cat. n° 7938, 1:500), NF-κB (Cell Signaling Technology, Cat.n° 8242, 1:800), and AMH (Santa Cruz Bıotechnology, Oregon, ABD-sc 1667529; 1:150) were treated with the sections for an entire night at 4°C.

Techniques: Immunohistochemical staining, Staining, Control, Expressing

Journal: Clinics

Article Title: Comparative efficacy of melatonin and glutathione in mitigating carboplatin-induced ovarian toxicity in rats

doi: 10.1016/j.clinsp.2026.100902

Figure Lengend Snippet: Evaluation of immünreactivity scores in ovarian tissue. Bar graphs showing the mean ± SD values for Cas-3, NF-κB, and AMH immunoreactivity scores. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001.

Article Snippet: Primary antibodies cleaved Cas-3 (Cell Signaling Technology, Cat. n° 7938, 1:500), NF-κB (Cell Signaling Technology, Cat.n° 8242, 1:800), and AMH (Santa Cruz Bıotechnology, Oregon, ABD-sc 1667529; 1:150) were treated with the sections for an entire night at 4°C.

Techniques: